The Drinks Bring Back All The Memories

In this episode, podcast host and Paradromics CEO, Matt Angle brings together memory-researchers Nanthia Suthana (Assist. Prof. of Neurosurgery and Bioengineering, UCLA School of Medicine) and Gyorgy Buzsaki (Biggs Professor of Neuroscience, NYU School of Medicine), and scientist-entrepreneurs Dan Rizzuto (CEO of Nia Therapeutics) and Nick Halper (Co-Founder of Braingrade) to discuss memory and neurotechnology.

Like many of you I approached, and to some extent still do approach, the concept of memory enhancement with skepticism. But the conversation today is going to be a grounded one, and I think you will see that there is some real science here that can give us reason to be cautiously optimistic about the future of memory and BCI. I hope you enjoy the episode.
– Matt Angle, CEO, Paradromics

00:43 | Guest Introductions‍

01:00 | Nia Therapeutics‍

01:36 | Larry Abbott‍

01:42 | Eve Marder‍

01:49 | Michael Kahana‍

02:43 | Suthana Lab‍

03:07 | Patient H.M.‍

04:06 | Blackrock Microsystems‍

04:39 | Peter Schlecht, CEO of Braingrade‍

05:08 | Buzsaki Lab‍

05:47 | Endre Grastyán‍

06:06 | Case Vanderwolf‍

06:45 | A Brief History of LTP‍

07:18 | Brenda Milner

07:38 | Types of Memory‍

09:31 | More on “Types of Memory”‍

10:52 | This is how Michael Kahana thinks of memory‍

11:42 | Stanford Encyclopedia of Philosophy: Memory‍

15:15 | Principles of Neural Science‍

17:01 | Fundamental Neuroscience‍

18:25 | Memory and Distance (spatial/temporal/semantic)‍

21:03 | After HM’s death, the extent of the lesion was assessed histologically‍

21:14 | The Legacy of HM for Neuroscience‍

22:29 | Endel Tulving: Episodic and Semantic Memory

26:47 | Building a Memory Prosthetic‍

26:56 | Matthew Kaufman‍

27:47 | Hippocampal Replay‍

22:01 | 2014 Nobel Prize in Medicine: Place Cells and Grid Cells‍

29:09 | Time Cells in the Hippocampus‍

30:04 | Buzsaki on Memory

38:05 | Predicting the Future: BCI to Decode/Reconstruct Memory‍

42:13 | Ray Kurzweil‍

42:33 | Famous Bad Predictions‍

42:48 | Henry’s Scale: Bluebrain Predictions‍

44:07 | Simonides‍

44:16 | The Art of Memory by Frances Yates‍

44:23 | William James, Primary and Secondary Memory‍

46:22 | Reconsolidation

46:26 | Clinical Evidence of Modulating Memory‍

46:31 | Mark Schnitzer‍

47:04 | Evidence of Memory Improvement by Neuromodulation‍

47:57 | UPenn Computational Memory Lab Publications‍

48:11 | medRxiv preprint‍

49:12 | DARPA: Restoring Active Memory‍

50:22 | Verbal Recall Improvement by Stimulating Lateral Temporal Cortex‍

50:46 | Ojemann 2009‍

51:52 | Long-duration hippocampal sharp wave ripples improve memory‍

53:30 | Up- and Down- States in Memory‍

54:53 | Multivariable Classifiers, Good Memory States‍

56:21 | Theta Phase Synchronization Is the Glue that Binds Human Associative Memory‍

56:25 | Network Coordination of Activity‍

57:48 | Matt makes a similar point here‍

59:06 | Medtronic Adaptive BCI‍

01:00:27 | Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation
Mechanisms and plasticity of chemogenically induced interneuronal suppression of principal cells

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1:02:52 | New Approaches For Enhancing Memory‍

1:06:03 | Boundary-anchored neural mechanisms of location-encoding for self and others‍

1:06:29 | See our Neurotech Pub episode on Dimensional Reduction for Large Datasets‍

1:11:15 | The Variability Puzzle in Human Memory‍

1:13:36 | Direct Brain Stimulation and Memory Performance in Humans‍

1:14:25 | Predicting Memory Function During Encoding and Retrieval
Interactions Between Episodic and Semantic Memory Systems‍

1:14:47 | Direct brain stimulation during episodic memory

1:17:48 | Closing the Research-Clinical Gap‍

1:17:50 | Jacob Robinson‍

1:19:16 | Theta Oscillations in the Human Medial Temporal Lobe during Real-World Ambulatory Movement‍

1:19:54 | Wireless Data Streaming from Adaptive DBS System‍

1:22:18 | More about Braingrade‍

1:24:04 | On single neurons vs LFP in Hippocampus‍

1:24:41 | Network Effect Studies [Toward a causal approach for the neural basis of memory]‍

1:26:55 | DBS and Memory Enhancement papers 1, 2, 3‍

1:27:59 | Responsive Neurostimulation for Post-Traumatic Stress Disorder‍

1:30:01 | Medtronic Percept‍

1:30:04 | Neuropace RNS‍

1:32:27 | Spike Phase Precession After Transient Intrahippocampal Perturbation‍

1:34:38 | Functional Neuromodulation ADvance II Study‍

1:34:58 | Dejan Markovic‍

1:35:01 | DARPA RAM Program Funds UCLA Team‍

1:37:05 | Balseal‍

1:37:50 | Neurotech Pub Episode 3: Connectors, Cans, and Coatings‍

1:40:43 | For some fun reading on memory as a skill, read “Moonwalking with Einstein“